01 · approved 2012
Linaclotide
United States
A guanylate cyclase-C peptide agonist for specific constipation disorders.
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Recent approved peptide medicines changing modern care
02 · approved 2010 / 2014
Liraglutide
Denmark
A GLP-1 analog used for diabetes and, under separate labeling, chronic weight management.
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03 · approved 2017
Plecanatide
United States
A uroguanylin analog for specific chronic constipation indications.
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04 · approved 2017 onward
Semaglutide
Denmark
A GLP-1 analog with separate products and indications in diabetes and chronic weight management.
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05 · approved 2022 onward
Tirzepatide
United States
A dual GIP/GLP-1 agonist with indication-specific approvals for diabetes and chronic weight management.
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06 · approved 2020 onward
Setmelanotide
United States
An MC4-receptor agonist for rare genetic and, later, acquired hypothalamic obesity indications.
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